A comparison of multiple imputation methods for bivariate hierarchical data: an application to cost-effectiveness analyse

نویسندگان

  • K Diaz-Ordaz
  • M Gomes
  • R Grieve
  • MG Kenward
چکیده

Methods We begin by illustrating the MI approaches with an example, a cost-effectiveness analysis of a CRT evaluating an intervention for postnatal depression (2659 participants, 100 clusters ICC for cost 0.17, ICC for QALYs 0.04). We conducted a simulation study to assess the performance of the alternative methods. Missing data scenarios were simulated according to factors hypothesized to influence performance, amongst them ICCs, number and size of clusters and the proportion of missing data.

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عنوان ژورنال:

دوره 14  شماره 

صفحات  -

تاریخ انتشار 2013